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KMID : 0882420060700050586
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Korean Journal of Medicine
2006 Volume.70 No. 5 p.586 ~ p.590
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A case of Stevens-Johnson syndrome caused by oxcarbazepine
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류동열/Ryu DR
송필상/이진영/이지영/오미정/이병재/최동철/Song PS/Lee JY/Rhee JY/Oh MJ/Lee BJ/Choi DC
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Abstract
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Stevens-Johnson syndrome and toxic epidermal necrolysis are acute life-threatening conditions. Aromatic antiepileptic drugs such as carbamazepine, phenytoin and phenobarbital are frequently associated with severe adverse cutaneous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Oxcarbazepine, a 10-keto derivative of carbamazepine has been reported to have a similar range of efficacy and fewer side effects than carbamazepine because it is a prodrug of a monohydroxy derivative. Because there are few clinical records of oxcarbazepine induced erythemamultiforme-like skin eruptsions, we reported a case of Stevens-Johnson syndrome thought to be caused by the use of oxcarbazepine in a 66-year-old male. Diffuse erythematous maculopapular eruptions were developed on his whole body 30 days after beginning with oxcarbazepine. The clinical and histologic findings of the patient were compatible with Stevens-Johnson syndrome. Although it is rare, oxcarbazepine can cause severe adverse cutaneous reactions.
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KEYWORD
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